Bioactive Hydrogel Marbles

Bioactive Hydrogel Marbles

Blog Article

Abstract Liquid marbles represented a significant advance click here in the manipulation of fluids as they used particle films to confine liquid drops, creating a robust and durable soft solid.We exploit this technology to engineering a bioactive hydrogel marble (BHM).Specifically, pristine bioactive glass nanoparticles were chemically tuned to produce biocompatible hydrophobic bioactive glass nanoparticles (H-BGNPs) that shielded a gelatin-based bead.The designed BHM shell promoted the growth of a bone-like apatite layer upon immersion in a physiological read more environment.

The fabrication process allowed the efficient incorporation of drugs and cells into the engineered structure.The BHM provided a simultaneously controlled release of distinct encapsulated therapeutic model molecules.Moreover, the BHM sustained cell encapsulation in a 3D environment as demonstrated by an excellent in vitro stability and cytocompatibility.The engineered structures also showed potential to regulate a pre-osteoblastic cell line into osteogenic commitment.

Overall, these hierarchical nanostructured and functional marbles revealed a high potential for future applications in bone tissue engineering.